Social connection
WHO Commission on Social Connection (2025)
The Commission's flagship report — From loneliness to social connection: charting a path to healthier societies — concludes that social disconnection carries mortality risk on par with smoking or obesity. One in six people globally reports loneliness; among adolescents it is one in five. The report links social isolation to a 32% higher stroke risk, a 29% higher risk of heart disease, and about 5% of global dementia risk.
Supporting meta-analyses: Luchetti et al. (2024, n>600,000) found loneliness raises all-cause dementia risk by 31% (HR 1.31; 95% CI 1.20–1.43). Smith et al. (2020) linked loneliness with elevated IL-6 and social isolation with elevated fibrinogen. Holt-Lunstad's 148-study meta-analysis reports social connection raises survival odds by 50%.
Nature exposure
Green-space meta-analyses (2018–2026)
The landmark Twohig-Bennett & Jones (2018) systematic review synthesised 143 studies and found significant reductions in diastolic BP (−1.97 mmHg), heart rate (−2.57 bpm), salivary cortisol (−0.05), incidence of type 2 diabetes, and cardiovascular mortality. A 2025 umbrella review of epidemiological meta-analyses confirmed protective effects on cardiovascular mortality, diabetes, metabolic syndrome, and mental illness.
Recent additions: a 2026 forest-bathing meta-analysis reported heart-rate drops of 4 bpm and lower anxiety/depression symptoms. Nature Cities (2025) confirmed substantial acute mental-health benefits from urban nature exposure. Roshanaei-Moghaddam et al. (2024) found greater green-space access cut hypertension odds by 19%, obesity by 17%, diabetes by 21%.